Metabolic Disease

L 152804 (Standard) is the analytical standard of L 152804 (HY-107734). This product is intended for research and analytical applications. L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

N-Hexanoyldihydrosphingosine (C6-dihydro-Ceramide (N-hexanoyl-)) is an ester product.

11,14-Eicosadienyl methane sulfonate (11,14-Eicosadien-1-ol,methanesulfonate) is an ester product.

SREBP/SCAP-IN-1(compound 10b) is a selectiveSREBP/SCAPinhibitor.

Saponarin (Standard) is the analytical standard of Saponarin (HY-N5083). This product is intended for research and analytical applications. Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders.

α Amylase-IN-1 (Compound 11) is an α-Amylase inhibitor with an IC₅₀ value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC₅₀ value of 53.49 μM for scavenging DPPH free radicals. IC₅₀ can be used in the study of diabetes and oxidative stress-related diseases.

RO-28-1675 (Standard) is the analytical standard of RO-28-1675 (HY-10595). This product is intended for research and analytical applications. RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC₅₀ of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

Ethyl 6(Z),9(Z),12(Z),15(Z),18(Z),21(Z)-tetracosahexaenoate is an ester product.

ω-Muricholic acid-d₄ (ω-MCA-d₄) is deuterium labeled ω-Muricholic Acid. ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.

11(E)-Vaccenyl methane sulfonate is an ester product.

MRS 1754 (Standard) is the analytical standard of MRS 1754. This product is intended for research and analytical applications. MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats.

1-Lauroyl-2-palmitoyl-rac-glycerol is a diacylglycerol that contains Lauric acid (HY-Y0366) at the sn-1 position and Palmitic acid (HY-N0830) at the sn-2 position.

Ethyl 13(Z),16(Z)-docosadienoate is an ester product.

Arachidyl myristate (Icosyl tetradecanoate) is an ester product.

CDN1163 (Standard) is the analytical standard of CDN1163 (HY-101455). This product is intended for research and analytical applications. CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

Elaidic acid ethyl ester (Ethyl 9(E)-octadecenoate) is an ester product.

Hexadecanedioic acid (Thapsic acid) (Standard) is the analytical standard of Hexadecanedioic acid (HY-W018161). This product is intended for research and analytical applications. Hexadecanedioic acid is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease.

MB-07811 (Standard) is the analytical standard of MB-07811 (HY-111288). This product is intended for research and analytical applications. MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity.

KSD 2405 (Standard) is the analytical standard of KSD 2405. This product is intended for research and analytical applications. KSD 2405 is an endogenous metabolite.

Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.